Projects

For children with rhabdomyosarcoma, assessing response to treatment and whether they remain in remission requires regular imaging such as MRI. In some types of cancer, but not rhabdomyosarcoma, it has been shown to be clinically useful to assess abnormal DNA released from a cancer into the blood stream.

Brain tumours are the main causes of mortality and morbidity of children, adolescents and young adults. Gliomas are the most frequent and the most fatal kind, among which the diffuse intrinsic pontic gliomas (or DIPG) represents the most severe form, universally incurable with hardly any patients surviving more than 2 years after the diagnosis.

This innovative clinical trial will test the combination of three classical metronomic chemotherapies with a PD-1 checkpoint inhibitor or Nivolumab®.

Thirty five thousand children, adolescents and young adults are diagnosed with cancer every year in Europe; among them 20% will not be cured. This projects aims at understanding the resistance mechanisms in the event of inefficacy of the first line treatments.