A molecule to sabotage neuroblastoma!

This project was selected in the framework of our European call: FIGHT KIDS CANCER 2020. It is jointly financed by Imagine for Margo, Kriibskrank Kanner Fondatioun and KickCancer.

Neuroblastoma is a tumour that mainly occurs in young children and derives from nerve cells located in the abdomen or next to the spine. The chances of survival for children with the aggressive form of this disease are very small. In addition, children who survive the disease often suffer later in life from health problems as a result of the treatment.

The projects’ researchers recently identified a key protein denoted as RRM2 that neuroblastoma cells rely on for sustained growth.

In this project “RESTRAIN”, researchers will create mouse and zebrafish models to cause a degradation of the RRM2 protein with the objective to improve our understanding of the role of RRM2 during neuroblastoma tumour formation. These novel preclinical models will also be explored to identify synergistic novel drugging strategies by using available small molecules.

In addition, the objective is to discover as many other proteins as possible that together with RRM2 play a crucial role in neuroblastoma cells and thus serve as novel targets for future therapy.


This project aims at identifying news treatment options for children with neuroblastoma. As a result, the project will benefit all children (Belgian, European and beyond!) if the study’s conclusions are encouraging.

A molecule to sabotage neuroblastoma!

  • Financed: 500 000€
    More than 85% of your donations go to financing research and supporting our advocacy work, less than 15% go to administration.
  • Duration: 2 year
  • Countries: Belgium and United Kingdom
  • Disease: Neuroblastoma
  • Status: To be started